SAB5500074

Anti-CD8 antibody, Rabbit monoclonal

Name: Anti-CD8 antibody, Rabbit monoclonal
Brand: SIGMA
Price: 374 USD

recombinant, expressed in proprietary host, clone SP16, tissue culture supernatant

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100 μL

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

SP16, monoclonal

Application:

IHC

Citations:

Key Documents

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biological source

rabbit

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

SP16, monoclonal

species reactivity

human (tested)

technique(s)

immunohistochemistry: 1:100

isotype

IgG

UniProt accession no.

P01732

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CD8A(925)

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Show Differences

1 of 4

This Item	SAB5500063	SAB5600130	SAB5600152
Sigma-Aldrich SAB5500074 Anti-CD8 antibody, Rabbit monoclonal	Sigma-Aldrich SAB5500063 Anti-CD38 antibody, Rabbit monoclonal	Sigma-Aldrich SAB5600130 Anti-CD5 antibody, Rabbit monoclonal	Sigma-Aldrich SAB5600152 Anti-CD4 antibody, Rabbit monoclonal
antibody form tissue culture supernatant	antibody form tissue culture supernatant	antibody form purified immunoglobulin	antibody form purified immunoglobulin
biological source rabbit	biological source rabbit	biological source -	biological source -
Gene Information human ... CD8A(925)	Gene Information human ... CD38(952)	Gene Information human ... CD5(921)	Gene Information human ... CD4(920)
conjugate unconjugated	conjugate unconjugated	conjugate -	conjugate -
clone SP16, monoclonal	clone SP149, monoclonal	clone RM314, monoclonal, recombinant monoclonal	clone RM345, monoclonal, recombinant monoclonal
species reactivity human (tested)	species reactivity human (tested)	species reactivity human	species reactivity human

General description

CD8 molecule consists of two chains, termed α and β chain, which are expressed as a disulphide-linked α/β heterdimer or as an α/α homodimer on T cell subset, thymocytes and NK cells. The majority of CD8+ T cells express CD8 as α/β heterdimer. CD8 functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 α chain (but not β chain).

Immunogen

Synthetic peptide corresponding to C-terminus of alpha chain of the human CD8 molecule.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy.

Tuba N Gide et al.

Cancer cell, 35(2), 238-255 (2019-02-13)

Cancer immunotherapies provide survival benefits in responding patients, but many patients fail to respond. Identifying the biology of treatment response and resistance are a priority to optimize drug selection and improve patient outcomes. We performed transcriptomic and immune profiling on

Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.

Barbara Ludwig et al.

Proceedings of the National Academy of Sciences of the United States of America, 114(44), 11745-11750 (2017-10-29)

Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets

WEE1 inhibitor and ataxia telangiectasia and RAD3-related inhibitor trigger stimulator of interferon gene-dependent immune response and enhance tumor treatment efficacy through programmed death-ligand 1 blockade.

Xue Wu et al.

Cancer science, 112(11), 4444-4456 (2021-08-13)

WEE1 plays an important role in the regulation of cell cycle G2/M checkpoints and DNA damage response (DDR). Inhibition of WEE1 can increase the instability of the genome and have anti-tumor effects in some solid tumors. However, it has certain

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