SAB5500151

Anti-Neutrophil Elastase antibody, Rabbit monoclonal

clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody

• NACRES: NA.41
• UNSPSC Code: 12352203

Properties

• Product Name: Anti-Neutrophil Elastase antibody, Rabbit monoclonal, clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody
• biological source: rabbit
• recombinant: expressed in proprietary host
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: SP203, monoclonal
• species reactivity: human (tested)
• technique(s): immunohistochemistry: 1:100
• isotype: IgG
• UniProt accession no.: P08246
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Quality Level: 100
• Gene Information: human ... ELANE(1991)

Description

Biochem/physiol Actions

Neutrophil elastase (NE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. The encoded protein catalyzes the cleavage of tyrosyl-tRNA synthetase to produce cytokine domains that stimulates neutrophil chemotaxis. In addition, NE also facilitates the secretion of the neutrophil chemoattractant, interleukin-8 from endothelial cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Neutrophil elastase (NE) is a monomeric protein, encoded by the gene mapped to human chromosome 19p13.3. The protein has a molecular mass of 25 kDa and is mainly present in the neutrophil granules (located in the neutrophil cytoplasm).

Neutrophil elastase is a serine proteinase synthesized by promyelocytes and promonocytes. It is secreted by neutrophils to degrade extracellular matrix, and to destroy bacteria. It is used as a marker for myeloid leukemia cells.

Immunogen

Synthetic peptide from human neutrophil elastase protein.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable