SAB5500169

Sigma-Aldrich

Anti-PTEN antibody, Rabbit monoclonal

clone SP218, recombinant, expressed in proprietary host, affinity isolated antibody

NACRES:
NA.41

biological source

rabbit

Quality Level

recombinant

expressed in proprietary host

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

SP218, monoclonal

species reactivity

human (tested)

species reactivity (predicted by homology)

frog, mouse, dog

application(s)

flow cytometry: 1:200
immunoblotting: 1:400
immunohistochemistry: 1:200

isotype

IgG

conjugate

unconjugated

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... PTEN(5728)

General description

The defects of PTEN have been implicated in human cancers from breast, prostate, thyroid, skin, endometrium, head and neck, and brain. Up to 50-60 percent of advanced prostate cancers show abnormal PTEN gene expression or loss of protein expression.

Immunogen

Synthetic peptide derived from the C-terminus of human PTEN protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
J M Garcia et al.
Breast cancer research and treatment, 57(3), 237-243 (2000-01-05)
Loss of heterozygosity (LOH) in loci of the 10q23 region that harbor the PTEN gene and mutations in the sequence of this gene have been found in several primary human tumors including breast carcinomas, suggesting that this gene could be...
Pau Jané et al.
PloS one, 15(12), e0244613-e0244613 (2021-01-01)
Protein domains often recognize short linear protein motifs composed of a core conserved consensus sequence surrounded by less critical, modulatory positions. PTEN, a lipid phosphatase involved in phosphatidylinositol 3-kinase (PI3K) pathway, contains such a short motif located at the extreme...
Ziying Lin et al.
BMC cancer, 21(1), 429-429 (2021-04-21)
Recent evidences had shown that loss in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was associated with immunotherapy resistance, which may be attributed to the non-T-cell-inflamed tumor microenvironment. The impact of PTEN loss on tumor microenvironment, especially regarding...
Zhaoxin Jiang et al.
BMC ophthalmology, 20(1), 487-487 (2020-12-15)
Choroidal ganglioneuroma is an extremely rare tumor, and there is little knowledge regarding its pathogenesis. We aimed to investigate the phenotypic and genetic alterations in one sporadic patient with a rare case of bilateral choroidal ganglioneuroma. A 6-year-old boy with...

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