SAB5700315

Anti-Phospho-MAP3K7-S412 antibody produced in rabbit

• Synonym(s): CSCF, FMD2, MAP3K7, MEKK7, TAK1, TGF1a
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 53; 56; 64; 67
• species reactivity: human
• concentration: 0.99 mg/ml
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: O43318
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer412)
• Gene Information: human ... MAP3K7(6885)

Description

General description

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Immunogen

A phospho specific peptide corresponding to residues surrounding S412 of human MAP3K7

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety Information

• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable