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SAB5701213

Sigma-Aldrich

Anti- PD-L1/CD274 antibody produced in rabbit

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biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

monoclonal

form

liquid

species reactivity

human

concentration

1 mg/mL

technique(s)

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PD-L1(29126)

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This Item
SAB5701115SAB4301882SAB5701683
Anti-CD274 affinity isolated antibody

Sigma-Aldrich

SAB4301882

Anti-CD274

clone

monoclonal

clone

monoclonal

clone

polyclonal

clone

monoclonal

form

liquid

form

liquid

form

buffered aqueous glycerol solution

form

liquid

species reactivity

human

species reactivity

rat, mouse, monkey, human

species reactivity

human, mouse

species reactivity

human, rat, mouse

concentration

1 mg/mL

concentration

1.51 mg/mL

concentration

-

concentration

0.73 mg/mL

technique(s)

immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

technique(s)

immunohistochemistry: 1:50-1:100, immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

technique(s)

immunohistochemistry: 1: 20-100, western blot: 1:200-1:1000

technique(s)

immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

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General description

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Immunogen

A synthetic peptide of human PD-L1/CD274.

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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