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SBNMQ

Sigma-Aldrich

NMQ/N-methyl-quinidine - MDR1/P-gp Substrate

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Synonym(s):
SB-NMQ, N-methyl-quinidine (NMQ), NMQ
Empirical Formula (Hill Notation):
C21H27IN2O2
CAS Number:
42982-87-6
Molecular Weight:
466.36
NACRES:
NA.84

form

powder

color

white

storage temp.

room temp

InChI

1S/C21H27N2O2.HI/c1-4-14-13-23(2)10-8-15(14)11-20(23)21(24)17-7-9-22-19-6-5-16(25-3)12-18(17)19;/h4-7,9,12,14-15,20-21,24H,1,8,10-11,13H2,2-3H3;1H/q+1;/p-1/t14-,15?,20+,21-,23?;/m0./s1

InChI key

AJQSDVGBERUTGX-QVEQJUGRSA-M

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M5655767870SCP0200
Sigma-Aldrich

Sigma-Aldrich

SBNMQ

NMQ/N-methyl-quinidine - MDR1/P-gp Substrate

4-Methylmorpholine ReagentPlus®, 99%

Sigma-Aldrich

M56557

4-Methylmorpholine

4-Methylmorpholine purum, ≥98.0% (GC)

Sigma-Aldrich

67870

4-Methylmorpholine

Sigma-Aldrich

Sigma-Aldrich

SCP0200

Neuromedin N

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

−20°C

color

white

color

-

color

-

color

-

Application

NMQ/N-methyl-quinidine - MDR1/P-gp substrate has been used as a probe substrate for multidrug resistance protein 1 (MDR1) in vesicles assay.

Biochem/physiol Actions

SOLVO Biotechnology offers NMQ as a selective substrate for the MDR1 membrane transporter.

NMQ was shown to be actively transported by human MDR1/P-gp and rat Mdr1b efflux transporters.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Potential herb-drug interaction of shexiang baoxin pill in vitro based on drug metabolism/transporter.
Shen Z, et al.
American Journal of Translational Research, 8(12), 5545-5545 (2016)
Zhijie Shen et al.
American journal of translational research, 8(12), 5545-5556 (2017-01-13)
Many researches have proved functions of anti-oxidation, endothelial protection and pro-angiogenesis efficiency of Shexiang Baoxin Pill (SBP). This study aims to investigate potential for metabolism-based interaction on CYP450s and transporter based interaction on OATP1B1, BRCP and MDR1. Human primary hepatocytes

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