Stephen Hawser et al.
Biochemical pharmacology, 71(7), 941-948 (2005-12-20)
Although only a few DHFR inhibitors have progressed as antibiotics to the market there is much renewed interest in the discovery and development of new generation DHFR inhibitors as antibacterial agents. This article describes the success in exploiting DHFR as...
The binding of trimethoprim to bacterial dihydrofolate reductase.
D J Baker et al.
FEBS letters, 126(1), 49-52 (1981-04-06)
R N Brogden et al.
Drugs, 23(6), 405-430 (1982-06-01)
Trimethoprim, which has been widely available for several years in combination with sulphamethoxazole as co-trimoxazole, is now available for use alone in the treatment of acute uncomplicated urinary tract infections. Trimethoprim, which is active against a wide range of Gram-positive...
Mahamadou A Thera et al.
The Journal of infectious diseases, 192(10), 1823-1829 (2005-10-20)
Trimethoprim-sulfamethoxazole (TS) prophylaxis is recommended for persons living with human immunodeficiency virus infection and acquired immunodeficiency syndrome in Africa. TS and the antimalarial combination sulfadoxine-pyrimethamine (SP) share mechanisms of action and resistance patterns, and concerns about the impact of TS...
Antimicroboial Drug Resistance: Sulfonamides and Trimethoprim
Skold, O.E., et al. et al.
Antimicrobial Drug Resistance, 345-358 (2017)