CF™488A is a green fluorescent dye optimally excitable by the 488 nm argon laser line. Under common detection conditions, CF™488A is at least as bright as Alexa Fluor™ 488. However, a major advantage of CF™488A over Alexa Fluor™ 488 is that antibody conjugates prepared from the former are biologically more specific. Alexa Fluor™ 488 carries multiple negative charges, which can significantly change the isoelectric point of the proteins the dye labels and consequently alter the specificity of the protein conjugates. CF™488A, on the other hand, is minimally charged. Thus, antibody conjugates prepared from the dye ensure biological detection with high signal-to-noise ratio. Another feature of CF™488A is that the emission peak wavelength is about 10 nm shorter than that of Alexa Fluor™ 488 and 15 nm shorter than that of the traditional green dye FITC (or FAM). The shorter wavelength of CF™488A offers the advantage of less fluorescence "spill-over" in the red channel in multi-color detection applications.
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ALEXA FLUOR is a trademark of Life Technologies
CF is a trademark of Biotium, Inc.
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