Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design
Taylor SS, et al.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1784(1), 16-26 (2008)
Barbara Wienen-Schmidt et al.
ChemMedChem, 16(1), 292-300 (2020-10-09)
In lead optimization, protein crystallography is an indispensable tool to analyze drug binding. Binding modes and non-covalent interaction inventories are essential to design follow-up synthesis candidates. Two protocols are commonly applied to produce protein-ligand complexes: cocrystallization and soaking. Because of...