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RNAi, Custom shRNA, High-throughput shRNA, MISSION® shRNA, Short hairpin RNA, Small hairpin RNA, inducible shRNA, shRNA, shRNA arrayed, shRNA gene sets, shRNA library, shRNA panels, shRNA pools, targeted integration shRNA
Plasmids: shopping in the age of plenty.
Vivien Marx
Nature methods, 11(8), 795-798 (2014-07-31)
Carole Siret et al.
British journal of cancer, 113(10), 1445-1453 (2015-10-30)
Malignant transformation of melanocytes frequently coincides with an alteration in the expression of cell-cell adhesion molecules (cadherins) and cell-extracellular matrix proteins (integrins). How these two adhesion systems interplay to impact on cell invasion remains to be described in melanoma. Cell
Panagiotis Maragozidis et al.
Molecular cancer, 14, 187-187 (2015-11-07)
Lung cancer is the leading cause of cancer mortality worldwide, mainly due to late diagnosis, poor prognosis and tumor heterogeneity. Thus, the need for biomarkers that will aid classification, treatment and monitoring remains intense and challenging and depends on the
Hélène Lazareth et al.
Nature communications, 10(1), 3303-3303 (2019-07-26)
The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we
Xiaofan Han et al.
Nature communications, 8, 14639-14639 (2017-03-04)
Endothelial exocytosis of Weibel-Palade body (WPB) is one of the first lines of defence against vascular injury. However, the mechanisms that control WPB exocytosis in the final stages (including the docking, priming and fusion of granules) are poorly understood. Here

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The Researcher’s Guide to Designing CRISPR and RNAi Screening Experiments

This screening guide covers how to choose a cell line, a screening library, and experimental conditions as well as tips for designing and performing your experiment.

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