Ruscogenin is a major steroidal saponin found in the root of Ophiopogon japonicus. It was first isolated from Ruscus aculeatus.
Application
Ruscogenin has been used to study its therapeutic effects on Crohn′s disease (CD)-like colitis both in vitro and in vivo studies.
Biochem/physiol Actions
Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-κB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.
Journal of pharmacological sciences, 108(2), 198-205 (2008-10-24)
Ruscogenin (RUS), first isolated from Ruscus aculeatus, also a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been found to exert significant anti-inflammatory and anti-thrombotic activities. Our previous studies suggested that ruscogenin remarkably inhibited adhesion of leukocytes
International immunopharmacology, 12(1), 88-93 (2011-11-15)
Acute lung injury is still a significant clinical problem with a high mortality rate and there are few effective therapies in clinic. Here, we studied the inhibitory effect of ruscogenin, an anti-inflammatory and anti-thrombotic natural product, on lipopolysaccharide (LPS)-induced acute
Domains of muscarinic acetylcholine receptors that confer specificity of G protein coupling.
T I Bonner
Trends in pharmacological sciences, 13(2), 48-50 (1992-02-01)
World journal of surgery, 16(2), 222-226 (1992-03-01)
This retrospective study examines the experience of the Sydney Melanoma Unit in the management of cervical lymph nodes among patients with cutaneous melanoma of the head and neck. From 1960 to 1990, 397 patients had neck dissections for cutaneous malignant
Oxidative medicine and cellular longevity, 2022, 4877275-4877275 (2022-03-22)
Interaction of intestinal barrier dysfunction and intestinal inflammation promotes the progression of Crohn's disease (CD). A more recent study has suggested that ruscogenins (RUS) can exert anti-inflammatory effects through activation of the Nrf2/NQO1 pathway. The current study is aimed at
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