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SMB00607

Sigma-Aldrich

Amoxicillin trihydrate: potassium clavulanate (4:1)

Synonym(s):

Amoxicillin Trihydrate: Potassium Clavulanate

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1 G
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$221.00

About This Item

UNSPSC Code:
51285005
NACRES:
NA.85

$221.00

In StockDetails

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form

powder

Quality Level

200

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)

color

white to yellow

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

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This Item
A61403158631591
Amoxicillin trihydrate: potassium clavulanate (4:1)

SMB00607

Amoxicillin trihydrate: potassium clavulanate (4:1)

Ampicillin trihydrate 900-1050 μg/mg anhydrous basis (HPLC)

A6140

Ampicillin trihydrate

Amoxicillin trihydrate VETRANAL®, analytical standard

31586

Amoxicillin trihydrate

Ampicillin trihydrate VETRANAL®, analytical standard

31591

Ampicillin trihydrate

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

form

powder

form

powder or crystals

form

-

form

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)

storage condition

-

storage condition

-

storage condition

-

color

white to yellow

color

-

color

-

color

white to off-white

General description

Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.[1]

Application

Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.[2]

Biochem/physiol Actions

Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria.[3][4] Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.

Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases[5] found in bacteria that are resistant to penicillins and cephalosporins.[6]

Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.[7]

Packaging

1G

Components

Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.

Storage and Stability

Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.

pictograms

FlameHealth hazard
GHS02,GHS08

signalword

Danger

Hazard Classifications

Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1

supp_hazards

EUH014,EUH044

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000410521
0000410521
0000368640
0000368640
0000174275

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Questions

  1. What are the uses and potential reactions of Amoxicillin and Clavulanate Potassium

    1 answer

    1. This product is supplied for research purposes with the primary use as an antibiotic. Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin's antibacterial activity against bacteria normally resistant to β-lactam antibiotics. Please see the peer-reviewed paper section in the link below for potential use information.

      https://www.sigmaaldrich.com/search/smb00607?focus=papers&page=1&perpage=30&sort=relevance&term=SMB00607&type=citation_search

      Products are not tested for safety and efficacy in food, drug, medical device, cosmetic, commercial, or any other use. Potential reactions or side effects are not evaluated.

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