SML0019

Sigma-Aldrich

VU0357121

≥98% (HPLC)

Synonym(s):
VU0357121, 4-Butoxy-N-(2,4-difluorophenyl)-benzamide
Empirical Formula (Hill Notation):
C17H17F2NO2
CAS Number:
Molecular Weight:
305.32
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

solubility

DMSO: ≥18 mg/mL

storage temp.

2-8°C

SMILES string

CCCCOc1ccc(cc1)C(=O)Nc2ccc(F)cc2F

InChI

1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21)

InChI key

AHCYOTLTLQTPSU-UHFFFAOYSA-N

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

VU0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action is distinct from the classical mGlu5 negative allosteric modulator (NAM) MPEP allosteric site or the site of a recetly discovered PAM, CPPHA. However, VU0357121shares a functional interaction with the MPEP site. VU0357121 is highly selective for activation of mGlu5 and is inactive or very weakly antagonizing at other mGlu receptor subtypes.

Certificate of Analysis

Certificate of Origin

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