SML0025

Safinamide mesylate salt

≥98% (HPLC)

• Synonym(s): (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;
• Empirical Formula (Hill Notation): C₁₇H₁₉FN₂O₂ · xCH₄O₃S
• CAS Number: 202825-46-5
• Molecular Weight: 302.34 (free base basis)
• MDL number: MFCD15145475
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825096
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
• color: white to tan
• solubility: H₂O: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
• InChI: 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
• InChI key: YKOCHIUQOBQIAC-YDALLXLXSA-N
• Gene Information: human ... MAOB(4129)

Description

Application

Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).[1]

Safinamide mesylate salt may be used in cell signaling studies.

Biochem/physiol Actions

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

Safinamide is a sodium and calcium channel blocker that is also a selective and reversible inhibitor of monoamine oxidase type B (MAO-B); anticonvulsant

Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

Features and Benefits

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H319,H361d
• pcodes: P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable