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MilliporeSigma

SML0034

1-EBIO

≥98% (HPLC)

Synonym(s):

1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one; 1-Ethylbenzimidazolinone

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About This Item

Empirical Formula (Hill Notation):
C9H10N2O
CAS Number:
10045-45-1
Molecular Weight:
162.19
NACRES:
NA.77
PubChem Substance ID:
329825104
UNSPSC Code:
12352200
EC Number:
233-148-1
MDL number:
MFCD00005715
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

1-EBIO, ≥98% (HPLC)

InChI key

CXUCKELNYMZTRT-UHFFFAOYSA-N

InChI

1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)

SMILES string

CCN1C(=O)Nc2ccccc12

assay

≥98% (HPLC)

form

powder

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

Quality Level

100

Application

1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons.[1] The effect of 1-EBIO on human intermediate conductance channels was studied.[2]

Biochem/physiol Actions

1-EBIO is an activator of epithelial Ca2+-activated K+ channel also known as the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) or KCa3.1.
1-EBIO is an activator of epithelial Ca2+-activated K+ channel
1-EBIO potentiates the secretion of CFTR-mediated Cl− ion secretion by activating the basolateral KCNN4 K+ channels in native human colonic tissues.[3] It stimulates the apical Cl− channels and Ca+2-dependent basolateral K+ channels to stimulate fluid transport in lacrimal glands.[4]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000157676
0000157009
0000157676
0000156239
0000156239

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Patrick J Mulholland et al.
Biological psychiatry, 69(7), 625-632 (2010-11-09)
Small conductance calcium-activated potassium type 2 channels (SK2) control excitability and contribute to plasticity by reducing excitatory postsynaptic potentials. Recent evidence suggests that SK2 channels form a calcium-dependent negative-feedback loop with synaptic N-methyl-D-aspartate (NMDA) receptors. Addiction to alcohol and other
P Pedarzani et al.
The Journal of biological chemistry, 276(13), 9762-9769 (2001-01-13)
In most central neurons, action potentials are followed by an afterhyperpolarization (AHP) that controls firing pattern and excitability. The medium and slow components of the AHP have been ascribed to the activation of small conductance Ca(2+)-activated potassium (SK) channels. Cloned
F Woodward Hopf et al.
Neuron, 65(5), 682-694 (2010-03-13)
The cellular mechanisms underlying pathological alcohol seeking remain poorly understood. Here, we show an enhancement of nucleus accumbens (NAcb) core action potential firing ex vivo after protracted abstinence from alcohol but not sucrose self-administration. Increased firing is associated with reduced
Audrey E Padula et al.
Translational psychiatry, 10(1), 414-414 (2020-11-29)
Mood disorders are often comorbid with alcohol use disorder (AUD) and play a considerable role in the development and maintenance of alcohol dependence and relapse. Because of this high comorbidity, it is necessary to determine shared and unique genetic factors
Eva K Roth et al.
PloS one, 6(8), e24445-e24445 (2011-09-13)
The identification of strategies to improve mutant CFTR function remains a key priority in the development of new treatments for cystic fibrosis (CF). Previous studies demonstrated that the K⁺ channel opener 1-ethyl-2-benzimidazolone (1-EBIO) potentiates CFTR-mediated Cl⁻ secretion in cultured cells
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