SML0097

Nevirapine

≥98% (HPLC), HIV-1 reverse transcriptase inhibitor, powder

• Synonym(s): 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
• Empirical Formula (Hill Notation): C₁₅H₁₄N₄O
• CAS Number: 129618-40-2
• Molecular Weight: 266.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825155
• NACRES: NA.77
• MDL number: MFCD00866928
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100

Properties

• Product Name: Nevirapine,
• SMILES string: CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
• InChI: 1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
• InChI key: NQDJXKOVJZTUJA-UHFFFAOYSA-N
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥22 mg/mL
• storage temp.: room temp
• Quality Level: 100

Description

Application

Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication,[1] primary hepatocytes[2] and bone marrow dendritic cells (BMDCs).[3]

Biochem/physiol Actions

NNRTI (non-nucleoside reverse transcriptase inhibitor) of HIV-1

Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase.[4] It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.[2]

Nevirapine is an allosteric, non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The K_i for inhibition of wild-type RT by Nevirapine is 200 nM.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable