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SML0343

Sigma-Aldrich

Methylstat

≥98% (HPLC)

Synonym(s):

(2E)-4-[Hydroxy[4-[[[4-[[[(1-naphthalenylamino)carbonyl]oxy]methyl]phenyl]methyl]amino]butyl]amino]-4-oxo-2-butenoic acid methyl ester

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$213.00
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$812.00

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5 MG
$213.00
25 MG
$812.00

About This Item

Empirical Formula (Hill Notation):
C28H31N3O6
CAS Number:
Molecular Weight:
505.56
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

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$213.00


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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

O=C(NC1=CC=CC2=C1C=CC=C2)OCC3=CC=C(CNCCCCN(O)C(/C=C/C(OC)=O)=O)C=C3

InChI

1S/C28H31N3O6/c1-36-27(33)16-15-26(32)31(35)18-5-4-17-29-19-21-11-13-22(14-12-21)20-37-28(34)30-25-10-6-8-23-7-2-3-9-24(23)25/h2-3,6-16,29,35H,4-5,17-20H2,1H3,(H,30,34)/b16-15+

InChI key

MUJOCHRZXRZONW-FOCLMDBBSA-N

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Show Differences

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SML2657SML1915SML0461
MP-A08 ≥98% (HPLC)

SML2657

MP-A08

T-26c ≥98% (HPLC)

SML1915

T-26c

PH-002 ≥98% (HPLC)

SML0461

PH-002

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >5 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL (clear solution)

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs).
Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs). Methylstat inhibits the activity of JMJD2C (IC50 = 4.3 μM), with similar potency against JMJD2E and JMJD3. The compound has poor activity against dimethyl demethylases, and does not inhibit class I or II HDACs. Methylsat blocks proliferation of the esophageal carcinoma cell line KYSE150 with an IC50 value of 5.1 μM.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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