SML0358

AA74-1

≥98% (HPLC)

• Synonym(s): [4-(4-Hydroxy-2,6-dimethylheptan-4-yl)-2H-1,2,3-triazol-2-yl](pyrrolidin-1-yl)methanone, [4-[1-Hydroxy-3-methyl-1-(2-methylpropyl)butyl]-2H-1,2,3-triazol-2-yl]-1-pyrrolidinylmethanone
• Empirical Formula (Hill Notation): C₁₆H₂₈N₄O₂
• CAS Number: 1361532-00-4
• Molecular Weight: 308.42
• MDL number: MFCD23704789
• PubChem Substance ID: 329825360
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: film
• color: colorless
• solubility: DMSO: >15 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(C)CC(O)(CC(C)C)c1cnn(n1)C(=O)N2CCCC2
• InChI: 1S/C16H28N4O2/c1-12(2)9-16(22,10-13(3)4)14-11-17-20(18-14)15(21)19-7-5-6-8-19/h11-13,22H,5-10H2,1-4H3
• InChI key: GXBVPGCIMCIASQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

AA74-1 is an extremely potent and selective inhibitor of the serine hydrolase acyl-peptide hydrolase (APEH) with an IC₅₀ of 5 nM in mouse T-cell proteomes. AA74-1 potently blocked the activity of its target serine hydrolase, APEH, in mice in vivo without significantly affecting other enzymes. The APEH inhibition caused accumulation of N-acetylated proteins and stimulated cellular proliferation in T cells.

The APEH gene is deleted in some cancers, in which it has been proposed to serve as a potential tumor suppressor, and is involved in the degradation of oligomeric amyloid-beta which could make it a new target for therapy aimed at reducing neurodegeneration in Alzheimer′s disease. AA74-1 is the first selective tool for studying APEH activity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable