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SML0428

Sigma-Aldrich

GSK690693

≥98% (HPLC)

Synonym(s):

4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol

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$197.00
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$390.50

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5 MG
$197.00
25 MG
$390.50

About This Item

Empirical Formula (Hill Notation):
C21H27N7O3
CAS Number:
937174-76-0
Molecular Weight:
425.48
MDL number:
MFCD14105605
UNSPSC Code:
12352200
PubChem Substance ID:
329825423
NACRES:
NA.77

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c4nonc4N

InChI

1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1

InChI key

KGPGFQWBCSZGEL-ZDUSSCGKSA-N

Gene Information

human ... AKT1(207), AKT2(208), AKT3(10000), PRKACA(5566), PRKACB(5567), PRKACG(5568), PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584), PRKCQ(5588), PRKCZ(5590), PRKD1(5587), PRKD3(23683)

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Show Differences

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GSK690693 ≥98% (HPLC)

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SML2718

GSK503

AZ12799734 ≥98% (HPLC)

SML2819

AZ12799734

GSK-J4 ≥98% (HPLC)

SML0701

GSK-J4

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL (clear solution)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Application

GSK690693 has been used in western blotting and immunoprecipitations.[1]

Biochem/physiol Actions

4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol/GSK690693[2] is a protein kinase B/AKT inhibitor. GSK690693 can prevent growth and apoptosis in acute lymphoblastic leukemia cell lines.[3]
GSK690693 is a potent pan-AKT kinase inhibitor.
GSK690693 is an ATP competitive, potent pan-AKT kinase inhibitor with IC50 values of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000169321
103M4702V
072M4621V

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