SML0500

GSK334429 hydrochloride

Name: GSK334429 hydrochloride
Brand: SIGMA
Price: 123.25 USD
Availability: InStock

≥98% (HPLC)

Synonym(s):

1-(1-Methylethyl)-4-((1-(6-(trifluoromethyl)-3-pyridinyl)-4-piperidinyl)carbonyl)hexahydro-1H-1,4-diazepine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₉F₃N₄O · xHCl

CAS Number:

799558-94-4

Molecular Weight:

398.47 (free base basis)

MDL number:

MFCD22666404

UNSPSC Code:

12352200

PubChem Substance ID:

329825449

NACRES:

NA.77

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

Cl.CC(C)N1CCCN(CC1)C(=O)C2CCN(CC2)c3ccc(nc3)C(F)(F)F

InChI

1S/C20H29F3N4O.ClH/c1-15(2)25-8-3-9-27(13-12-25)19(28)16-6-10-26(11-7-16)17-4-5-18(24-14-17)20(21,22)23;/h4-5,14-16H,3,6-13H2,1-2H3;1H

InChI key

RCZVWLOXPFGZDD-UHFFFAOYSA-N

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Show Differences

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This Item	SML0766	SML2169	SML2331
Sigma-Aldrich SML0500 GSK334429 hydrochloride	Sigma-Aldrich SML0766 GSK343	Sigma-Aldrich SML2169 Diphenidol hydrochloride	Sigma-Aldrich SML2331 Perospirone hydrochloride
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level -	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: 5 mg/mL (clear solution)	solubility DMSO: 15 mg/mL, clear	solubility H₂O: 2 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear
storage condition desiccated	storage condition -	storage condition desiccated	storage condition desiccated

Biochem/physiol Actions

GSK334429 is a selective histamine H3 receptor antagonist.

GSK334429 is a selective histamine H3 receptor antagonist. H3 antagonists increase the release of brain histamine, ACh, NE and DA neurotransmitters that modulate cognitive processes. Studies look at their analgesic efffects including efficacy for neuropathic pain.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Store desiccated; dry room.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

092M4629V

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GSK334429 hydrochloride