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SML0525

Sigma-Aldrich

kb-NB142-70

≥97% (HPLC)

Synonym(s):

3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one

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5 MG
$148.00
25 MG
$584.00

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5 MG
$148.00
25 MG
$584.00

About This Item

Empirical Formula (Hill Notation):
C11H9NO2S2
CAS Number:
1233533-04-4
Molecular Weight:
251.32
MDL number:
MFCD18086915
UNSPSC Code:
12352200
PubChem Substance ID:
329825531
NACRES:
NA.77

$148.00

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Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

Oc1ccc2sc3C(=O)NCCSc3c2c1

InChI

1S/C11H9NO2S2/c13-6-1-2-8-7(5-6)9-10(16-8)11(14)12-3-4-15-9/h1-2,5,13H,3-4H2,(H,12,14)

InChI key

DHUAGGSHTKPOHU-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
SML0450SML1970SML1944
kb-NB142-70 ≥97% (HPLC)

SML0525

kb-NB142-70

5-BDBD ≥98% (HPLC)

SML0450

5-BDBD

PKUMDL-WQ-2101 ≥98% (HPLC)

SML1970

PKUMDL-WQ-2101

Bz-423 ≥98% (HPLC)

SML1944

Bz-423

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 15 mg/mL (clear solution)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

light yellow to dark orange

color

white to beige

Biochem/physiol Actions

kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC50 for inhibition of PKD1 = 28.3 nM vs. 182 nM for CID755673). kb-NB142-70 dose dependently inhibits proliferation of PC3 prostate cancer cell, and blocks migration of the prostate cancer lines PC3 and DU145.
kb-NB142-70 is a protein kinase D (PKD1) inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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