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  • SML0543
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SML0543

Sigma-Aldrich

p38 MAP Kinase Inhibitor IV

≥98% (HPLC)

All Photos(1)
Synonym(s):
2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol), B10, MT4
Empirical Formula (Hill Notation):
C12H4Cl6O4S
CAS Number:
1638-41-1
Molecular Weight:
456.94

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InSolution p38 MAP Kinase Inhibitor III - Calbiochem The InSolution p38 MAP Kinase Inhibitor III controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

506148

InSolution p38 MAP Kinase Inhibitor III - Calbiochem

The InSolution p38 MAP Kinase Inhibitor III controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SB 203580 solid, ≥98% (HPLC)

Sigma-Aldrich

S8307

SB 203580

solid, ≥98% (HPLC)

SB 239063 >98% (HPLC)

Sigma-Aldrich

S0569

SB 239063

>98% (HPLC)

Sigma-Aldrich

Sigma-Aldrich

19-135

p38/SAPK2 Inhibitor (SB 203580)

The p38/SAPK2 Inhibitor (SB 203580) controls the biological activity of p38/SAPK2. This small molecule/inhibitor is primarily used for Biochemicals applications.

SB 239063 - CAS 798558-40-4 - Calbiochem A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the α- and β-isoforms (IC₅₀ = 44 nM), but not the γ- or δ-isoform (IC₅₀ > 100 µM), of MAP kinase p38.

Sigma-Aldrich

559404

SB 239063 - CAS 798558-40-4 - Calbiochem

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the α- and β-isoforms (IC₅₀ = 44 nM), but not the γ- or δ-isoform (IC₅₀ > 100 µM), of MAP kinase p38.

SB 203580 - CAS 152121-47-6 - Calbiochem SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

Sigma-Aldrich

559389

SB 203580 - CAS 152121-47-6 - Calbiochem

SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

SB 202190 ≥98% (HPLC)

Sigma-Aldrich

S7067

SB 202190

≥98% (HPLC)

PD 169316 ≥98% (HPLC), solid

Sigma-Aldrich

P9248

PD 169316

≥98% (HPLC), solid

SP600125 ≥98% (HPLC)

Sigma-Aldrich

S5567

SP600125

≥98% (HPLC)

PD 98,059 solid

Sigma-Aldrich

P215

PD 98,059

solid

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Application

p38 MAP Kinase Inhibitor IV has been used for blocking p38α kinase activation in order to examine if HOXB7 is involved in the regulation of migration and proliferation process via AKT/MAPK signaling.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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