SML0583

Sigma-Aldrich

Ferrostatin-1

≥95% (HPLC)

Synonym(s):
3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;
Empirical Formula (Hill Notation):
C15H22N2O2
CAS Number:
Molecular Weight:
262.35
NACRES:
NA.77

Quality Level

assay

≥95% (HPLC)

form

powder

color

, faint purple to brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Application

Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.
Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
Zilka O, et al.
ACS central science, 3(3), 232-243 (2017)
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Mai T T, et al.
Nature Chemistry, 9(10), 1025-1025 (2017)
The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells.
Kabiraj P, et al.
The Protein Journal, 34(5), 349-358 (2015)
Farhan Basit et al.
Cell death & disease, 8(3), e2716-e2716 (2017-03-31)
Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 ('BAY') triggers death of BRAFV600E melanoma cell lines and inhibits in vivo tumor growth. Here we studied the mechanism by which this inhibition induces melanoma cell death....
Rachel P L van Swelm et al.
Cell death & disease, 9(5), 550-550 (2018-05-12)
Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement...

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