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  • SML0583
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SML0583

Sigma-Aldrich

Ferrostatin-1

≥95% (HPLC)

Synonym(s):
3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;
Empirical Formula (Hill Notation):
C15H22N2O2
CAS Number:
Molecular Weight:
262.35
NACRES:
NA.77

Quality Level

Assay

≥95% (HPLC)

form

powder

color

, faint purple to brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

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Ferrocene for synthesis

Sigma-Aldrich

8.03978

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Supelco

PHR1482

Ferrous Fumarate

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98.0% (GC)

assay

-

form

powder

form

powder

form

crystals

form

-

color

, faint purple to brown

color

yellow to brown

color

-

color

-

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

2-30°C

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

300

Application

Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.

Biochem/physiol Actions

Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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