SML0739

TAPI-1 acetate salt

≥97% (HPLC)

• Synonym(s): N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-Alaninamide acetate salt
• Empirical Formula (Hill Notation): C₂₆H₃₇N₅O₅ · xC₂H₄O₂
• CAS Number: 163847-77-6
• Molecular Weight: 499.60 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: N(O)C(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cc2c(cc1)cccc2)C(=O)N[C@@H](C)C(=O)NCCN
• InChI: 1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21+,22-/m0/s1
• InChI key: AWNBSWDIOCXWJW-WTOYTKOKSA-N

Description

Application

TAPI-1 acetate salt has been used as a tumor necrosis factor(TNF)-α convertase/ADAM17/α-secretase (TACE) inhibitor.[1][2]

Biochem/physiol Actions

TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase).

TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable