SML0791

N,N-Dimethyltryptamine

≥97% (HPLC)

• Synonym(s): DMT, N,N-Dimethyl-1H-indole-3-ethanamine, Dimethyltryptamine
• Empirical Formula (Hill Notation): C₁₂H₁₆N₂
• CAS Number: 61-50-7
• Molecular Weight: 188.27
• MDL number: MFCD00055989
• PubChem Substance ID: 329825600
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• drug control: USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CN(C)CCC1=CNC2=C1C=CC=C2
• InChI: 1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3
• InChI key: DMULVCHRPCFFGV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

N,N-Dimethyltryptamine (DMT) is a hallucinogen now known to be an endogenous sigma-1 receptor agonist. In keeping with the known sigma-1 receptor modulation of voltage gated Na+ channels, DMT was found to reversibly inhibit Na currents by 62% in vitro. N,N-Dimethyltryptamine also induced hypermotility in WT mice (but not in sigma-1 KO mice), all evidence of its sigma-1 agonist activity.

N,N-Dimethyltryptamine (DMT) functions as a hallucinogen. Experimental studies states that DMT is an endogenous sigma-1 receptor agonist. DMT interacts with sigma-1 receptors and blocks voltage-gated sodium ion (Na⁺) channels in both native cardiac myocytes and heterologous cells that contain sigma-1 receptors.

Features and Benefits

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Other Notes

Product contains 1.2% wt. EtOH (by NMR and EA).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H336
• Precautionary Statements: P261 - P271 - P304 + P340 + P312 - P403 + P233 - P405 - P501
• Hazard Classifications: STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable