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SML0874

Sigma-Aldrich

GMQ hydrochloride

≥95% (HPLC)

Synonym(s):

2-Guanidine-4-methylquinazoline hydrochloride, 4-Methyl-2-guanidino quinazoline hydrochloride, N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride, NSC 403387 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H11N5 · HCl
CAS Number:
5361-15-9
Molecular Weight:
237.69
MDL number:
MFCD00035249
UNSPSC Code:
12352200
PubChem Substance ID:
329825612
NACRES:
NA.77

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Quality Level

100

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

CC1=NC(NC(N)=N)=NC2=C1C=CC=C2.Cl

InChI

1S/C10H11N5.ClH/c1-6-7-4-2-3-5-8(7)14-10(13-6)15-9(11)12;/h2-5H,1H3,(H4,11,12,13,14,15);1H

InChI key

VNPZWQRWOHFAPD-UHFFFAOYSA-N

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GMQ hydrochloride ≥95% (HPLC)

Sigma-Aldrich

SML0874

GMQ hydrochloride

Methylhexanamine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0460

Methylhexanamine hydrochloride

PF-2545920 hydrochloride ≥97% (HPLC)

Sigma-Aldrich

PZ0351

PF-2545920 hydrochloride

ORG 25543 Hydrochloride ≥95% (HPLC)

Sigma-Aldrich

SML2417

ORG 25543 Hydrochloride

form

powder

form

powder

form

powder

form

powder

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

H2O: 5 mg/mL (clear solution)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

Biochem/physiol Actions

GMQ/2-Guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation.
GMQ/2-guanidine-4-methylquinazoline is a potent and selective modulator of acid-sensing ion channel (ASIC).

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000080487
0000072530
0000027296
0000016671
126M4709V

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