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SML1013

PRT4165

≥98% (HPLC)

Synonym(s):

2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione; 2-(3-Pyridylmethylene)-1,3-indandione, NSC 600157

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5 MG

$99.45

25 MG

$460.00

$99.45

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About This Item

Empirical Formula (Hill Notation):
C15H9NO2
CAS Number:
31083-55-3
Molecular Weight:
235.24
MDL number:
MFCD00435709
UNSPSC Code:
12352200
PubChem Substance ID:
329825631
NACRES:
NA.77

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to gray

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C(C(C2=C1C=CC=C2)=O)=CC3=CN=CC=C3

InChI

1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H

InChI key

OMHZFEWYVFWVLI-UHFFFAOYSA-N

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This Item
SML0186SML1728SML2679
PRT4165 ≥98% (HPLC)

Sigma-Aldrich

SML1013

PRT4165

Dp44mT ≥98% (HPLC)

Sigma-Aldrich

SML0186

Dp44mT

STK16-IN-1 ≥98% (HPLC)

Sigma-Aldrich

SML1728

STK16-IN-1

PFF-1 ≥97% (HPLC)

Sigma-Aldrich

SML2679

PFF-1

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

yellow to orange

color

white to beige

color

white to beige

Biochem/physiol Actions

PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX.
PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000465755
0000465755
0000163476
0000163476
0000117351

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Dario Tommasini et al.
iScience, 26(4), 106358-106358 (2023-03-31)
Neurological disease is characterized the by dysfunction of specific neuroanatomical regions. To determine whether region-specific vulnerabilities have a transcriptional basis at cell-type-specific resolution, we analyzed gene expression in mouse oligodendrocytes across various brain regions. Oligodendrocyte transcriptomes cluster in an anatomical

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