SML1026

Lasofoxifene tartrate

Name: Lasofoxifene tartrate
Brand: SIGMA
Price: 131 USD
Availability: InStock

≥98% (HPLC)

Synonym(s):

(-)-cis-6-Phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol tartrate, (5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol tartrate, CP-336,156 tartrate

Slide 1 of 1

Sign Into View Organizational & Contract Pricing

Select a Size

10 MG

$131.00

50 MG

$446.25

$131.00

Available to ship TODAYDetails

Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):

C₂₈H₃₁NO₂ · C₄H₆O₆

CAS Number:

190791-29-8

Molecular Weight:

563.64

UNSPSC Code:

51111800

PubChem Substance ID:

329825634

NACRES:

NA.77

Key Documents

View All Documentation

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC=C(C(CC[C@@H]2C3=CC=CC=C3)=C1)[C@H]2C4=CC=C(OCCN5CCCC5)C=C4.O=C(O)[C@@H](O)[C@H](O)C(O)=O

InChI

1S/C28H31NO2.C4H6O6/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29;5-1(3(7)8)2(6)4(9)10/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2;1-2,5-6H,(H,7,8)(H,9,10)/t26-,28+;1-,2-/m10/s1

InChI key

INEHJXCWEVNEDZ-LUDNRVPPSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	H7904	H6278	SML0230
Sigma-Aldrich SML1026 Lasofoxifene tartrate	Sigma-Aldrich H7904 (Z)-4-Hydroxytamoxifen	Sigma-Aldrich H6278 4-Hydroxytamoxifen	Sigma-Aldrich SML0230 GW-803430
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 300	Quality Level 300	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition desiccated	storage condition desiccated, protect from light	storage condition desiccated, protect from light	storage condition -
solubility DMSO: 10 mg/mL, clear	solubility methanol: 10 mg/mL, ethanol: 20 mg/mL (with heating)	solubility methanol: 10 mg/mL, ethanol: 20 mg/mL (with heating)	solubility DMSO: ≥4 mg/mL at warmed to 60 °C

Biochem/physiol Actions

Lasofoxifene is a selective estrogen receptor modulator (SERM).

Lasofoxifene is a third-generation selective estrogen receptor modulator (SERM).

Lasofoxifene possesses strong resistance to intestinal wall glucuronidation and thus promotes oral bioavailability.[1] In postmenopausal women, it reduces bone resorption, bone loss and low density lipoprotein (LDL) cholesterol.[2] Selective and regular dose of Lasofoxifene is known to reduce the risk of fractures, breast cancer, major coronary heart disease, and stroke.[2]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000463040

0000237043

0000197232

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Lasofoxifene in postmenopausal women with osteoporosis.

Cummings S R, et al.

The New England Journal of Medicine, 362(8), 686-696 (2010)

Lasofoxifene: a third-generation selective estrogen receptor modulator for the prevention and treatment of osteoporosis.

Gennari L, et al.

Expert Opinion on Investigational Drugs, 15(9), 1091-1103 (2006)

Simultaneous separation and determination of 20 potential adulterant antigout and antiosteoporosis pharmaceutical compounds in herbal food products using LC with electrospray ionization MS/MS and LC with quadrupole-time-of-flight MS.

Nam Sook Kim et al.

Journal of separation science, 43(14), 2750-2765 (2020-04-17)

An analytical method for the simultaneous and reliable determination of 20 antigout and antiosteoporosis pharmaceutical compounds in adulterated health food products was developed using liquid chromatography with electrospray ionization tandem mass spectrometry and liquid chromatography with quadrupole-time-of-flight mass spectrometry. The

G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.

Kaitlyn J Andreano et al.

Breast cancer research and treatment, 180(3), 635-646 (2020-03-05)

The combination of targeting the CDK4/6 and estrogen receptor (ER) signaling pathways with palbociclib and fulvestrant is a proven therapeutic strategy for the treatment of ER-positive breast cancer. However, the poor physicochemical properties of fulvestrant require monthly intramuscular injections to

Simultaneous determination of illegal drug substances in dietary supplements for gout and osteoporosis using ultra-performance liquid chromatography and liquid chromatography-quadrupole-time-of-flight mass spectrometry.

Nam Sook Kim et al.

Journal of pharmaceutical and biomedical analysis, 179, 113003-113003 (2019-12-10)

The aim of this study was to simultaneously determine the presence of unauthorized drug substances in health foods and herbal products used in the treatment of conditions such as gout and anti-osteoporosis. Therefore, we developed and optimised a rapid and

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Lasofoxifene tartrate