SML1132

Pep2-8 trifluoroacetate salt

Name: Pep2-8 trifluoroacetate salt
Brand: SIGMA
Price: 214 USD

≥95% (HPLC), powder

Synonym(s):

Ac-TVFTSWEEYLDWV-NH₂ trifluoroacetate salt, Ac-TVFTSWEEYLDWV-amide trifluoroacetate salt, Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):

C₈₃H₁₁₀N₁₆O₂₄ · xC₂HF₃O₂

Molecular Weight:

1715.85 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

Key Documents

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Quality Level

100

assay

≥95% (HPLC)

form

powder

color

colorless to pale yellow

shipped in

wet ice

storage temp.

−20°C

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1 of 4

This Item	SML2626	SML2988	W3020
Sigma-Aldrich SML1132 Pep2-8 trifluoroacetate salt	Sigma-Aldrich SML2626 PEP87 trifluoroacetate salt	Sigma-Aldrich SML2988 Tat-NR2B9c trifluoroacetate	Sigma-Aldrich W3020 WKYMVdM trifluoroacetate salt
form solution	form film	form powder	form powder
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
color colorless to pale yellow	color white to beige	color white to off-white	color white to off-white
shipped in wet ice	shipped in -	shipped in -	shipped in -

Amino Acid Sequence

Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt

Biochem/physiol Actions

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that selectively binds to PCSK9 and interferes with LDL receptor binding to PCSK9. Pep2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells.

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor.

Pep2-8, a good mimic of epidermal growth factor precursor homology domain A (EGF-A)[1], serves as a competitive inhibitor of low-density lipoprotein (LDL) receptor binding.[2] It can be used as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site.[1]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.

Yingnan Zhang et al.

Nature structural & molecular biology, 24(10), 848-856 (2017-08-22)

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma LDL cholesterol (LDL-c) levels by promoting the degradation of liver LDL receptors (LDLRs). Antibodies that inhibit PCSK9 binding to the EGF(A) domain of the LDLR are effective in lowering LDL-c. However, the

Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.

Yingnan Zhang et al.

The Journal of biological chemistry, 289(2), 942-955 (2013-11-15)

PCSK9 (proprotein convertase subtilisin/kexin type 9) is a negative regulator of the hepatic LDL receptor, and clinical studies with PCSK9-inhibiting antibodies have demonstrated strong LDL-c-lowering effects. Here we screened phage-displayed peptide libraries and identified the 13-amino acid linear peptide Pep2-8

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Pep2-8 trifluoroacetate salt