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SML1142

Sigma-Aldrich

VU0071063

≥98% (HPLC)

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Synonym(s):
7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Empirical Formula (Hill Notation):
C18H22N4O2
CAS Number:
Molecular Weight:
326.39
MDL number:
PubChem Substance ID:

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C1=C2N(CC3=CC=C(C(C)(C)C)C=C3)C=N1)C(N(C)C2=O)=O

InChI

1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3

InChI key

ZFZAIHKQJBMYLO-UHFFFAOYSA-N

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This Item
D5385D0633SML2089
VU0071063 ≥98% (HPLC)

SML1142

VU0071063

1,7-Dimethylxanthine ~98%, solid

D5385

1,7-Dimethylxanthine

7-(2,3-Dihydroxypropyl)theophylline

D0633

7-(2,3-Dihydroxypropyl)theophylline

NCT-501 ≥98% (HPLC)

SML2089

NCT-501

assay

≥98% (HPLC)

assay

~98%

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

-

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, clear

solubility

ethanol: 0.6 mg/mL, H2O: 1 mg/mL, 0.1 M NaOH: 2 mg/mL

solubility

-

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white

color

-

color

white to beige

Biochem/physiol Actions

VU0071063 is a potent activator of Kir6.2/SUR1 KATP channels (EC50 = 10.3 μM). VU0071063 reversibly inhibits glucose-stimulated calcium influx in mouse β-islet cells. The compound VU0071063 has no affect on Kir6.2/SUR2A channels.
VU0071063 is also known as [7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione]. It serves as a major compound for examining β-cell physiology, KATP channel gating and a new chemical scaffold for evolving enhanced activators with medicinal chemistry.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Direct activation of beta-cell KATP channels with a novel xanthine derivative
Raphemot RS, et al.
Molecular Pharmacology, mol-114 (2014)

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