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SML1210

Almotriptan malate

≥98% (HPLC)

Synonym(s):

3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indole malate, PNU 180638

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About This Item

Empirical Formula (Hill Notation):
C17H25N3O2S · C4H6O5
CAS Number:
181183-52-8
Molecular Weight:
469.55
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

[S](=O)(=O)(N3CCCC3)Cc1cc2c([nH]cc2CCN(C)C)cc1.OC(CC(=O)O)C(=O)O

InChI

1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)

InChI key

QHATUKWEVNMHRY-UHFFFAOYSA-N

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1 of 4

This Item
1013512SML0248Y0002144
Almotriptan malate ≥98% (HPLC)

Sigma-Aldrich

SML1210

Almotriptan malate

USP

USP

1013512

Almotriptan malate

Zolmitriptan ≥98% (HPLC)

Sigma-Aldrich

SML0248

Zolmitriptan

vibrant-m

Y0002144

Almotriptan malate

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

form

powder

form

-

form

powder

form

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

H2O: 10 mg/mL, clear

solubility

-

solubility

DMSO: ≥5 mg/mL

solubility

-

Application

Almotriptan at an oral dose of 12.5 mg, is recommended to be safe for treating migraine.[1][2]
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.

Biochem/physiol Actions

Almotriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Almotriptan has low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower. Affinity for 5-HT(7) and 5-HT(1A) receptors was approximately 40 and 60 times lower than that for 5-HT(1B/1D) receptors, respectively.
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000406424
0000406424
015M4733V

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Dose finding, placebo-controlled study of oral almotriptan in the acute treatment of migraine
Dahlof C, et al.
Neurology, 57(10), 1811-1817 (2001)
Long?term Efficacy and Safety of Oral Almotriptan: Interim Analysis of a 1?Year Open Study
Cabarrocas X, et al.
Headache, 41(1), 57-62 (2001)
Kremena Saracheva et al.
Acta pharmaceutica (Zagreb, Croatia), 70(2), 239-247 (2020-01-20)
The introduction of the second generation triptans in clinical and experimental practice was a major progress in the pharmacotherapy of migraine. Frovatriptan is a second generation triptan with strong 5-HT1B/1D serotonergic agonism and low 5-HT1A/7 receptor affinity, while almotriptan possesses
Barbora Vyhlídalová et al.
International journal of molecular sciences, 21(8) (2020-04-23)
The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepatic and intestinal

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