Unfortunately, the stability of this product upon reconstitution has not been determined. It is recommended to use freshly prepared solutions. This product is shipped at ambient temperature during transport. However, for long-term storage, the powder form is maintained at 2-8°C. Please see the links below to publications reporting the stability of this material in solution:
https://pubmed.ncbi.nlm.nih.gov/20811032/
https://pubmed.ncbi.nlm.nih.gov/19108795/
SML1220
Doripenem hydrate
≥98% (HPLC), Ultra-broad spectrum carbapenem antibiotic, powder
Synonym(s):
(4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
Sign In to View Organizational & Contract Pricing.
About This Item
Empirical Formula (Hill Notation):
C15H24N4O6S2 · H2O
CAS Number:
Molecular Weight:
438.52
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Skip To
Product Name
Doripenem hydrate, ≥98% (HPLC)
SMILES string
[S](=O)(=O)(NC[C@H]1NC[C@H](C1)SC2=C(N3[C@H]([C@H]2C)[C@H](C3=O)[C@H](O)C)C(=O)O)N.O
InChI
1S/C15H24N4O6S2.H2O/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25;/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25);1H2/t6-,7-,8+,9+,10-,11-;/m1./s1
InChI key
NTUBEBXBDGKBTJ-WGLOMNHJSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Related Categories
1 of 4
This Item | SML1238 | I0160 | SML0306 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥90% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −70°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 5 mg/mL, clear (warmed) | solubility H2O: 20 mg/mL, clear | solubility H2O: >5 mg/mL | solubility H2O: ≥5 mg/mL (warmed) |
| color white to beige | color white to beige | color white to beige | color white to beige |
Biochem/physiol Actions
Doripenem hydrate is used to treat complicated urinary infection including Pyelonephritis caused by E.coli.[1] Doripenem hydrate is promoted in the United States as DORIBAX®.[1] This drug is synthesized from p-nitrobenzyl-protected enolphosphate 2b and N-(p-nitrobenzyloxycarbonyl)-protected aminomethylpyrrolidine.[2]
Doripenem is an ultra-broad spectrum carbopenem antibiotic.
Doripenem is an ultra-broad spectrum carbopenem antibiotic. Doripenem is active against both gram-positive and gram-negative bacteria.
Legal Information
DORIBAX is a registered trademark of Shionogi Inc.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Practical large-scale synthesis of doripenem: A novel 1β-methylcarbapenem antibiotic.
Nishino Y, et al.
Organic Process Research & Development, 7(6), 846-850 (2003)
Improved Large-scale One-pot Synthesis of Pure Doripenem Hydrate (S-4661).
Raju K R, et al.
Organic Prep. and Proc. Int., 48(4), 342-349 (2016)
Lokender Kumar et al.
Frontiers in microbiology, 12, 598498-598498 (2021-02-16)
Pseudomonas aeruginosa utilizes the quorum sensing (QS) system to strategically coordinate virulence and biofilm formation. Targeting QS pathways may be a potential anti-infective approach to treat P. aeruginosa infections. In the present study, we define cephalosporins' anti-QS activity using Chromobacterium
Articles
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
-
May I enquire on the recommended storage condition of the reconstituted working solution and the estimated shelf life of both the neat and working solution? Is there also a recommended transport temperature for the product?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service