SML1224

Torin2

Name: Torin2
Brand: SIGMA
Price: 161 USD
Availability: InStock

≥98% (HPLC), mTOR inhibitor, powder

Synonym(s):

9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₁₅F₃N₄O

CAS Number:

1223001-51-1

Molecular Weight:

432.40

UNSPSC Code:

12352200

NACRES:

NA.77

Key Documents

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Product Name

Torin2, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N

InChI

1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)

InChI key

GUXXEUUYCAYESJ-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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Show Differences

1 of 4

This Item	475992	475991	SML1728
Sigma-Aldrich SML1224 Torin2	Sigma-Aldrich 475992 mTOR Inhibitor XII, Torin2	Sigma-Aldrich 475991 mTOR Inhibitor XI, Torin1	Sigma-Aldrich SML1728 STK16-IN-1
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥99% (HPLC)	assay ≥99% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: 10 mg/mL	solubility DMSO: 2 mg/mL	solubility DMSO: 10 mg/mL, clear (warmed)
color white to beige	color yellow	color yellow-white	color white to beige

Application

Torin2 has been used:

to examine its effect on LC3B-II levels in BORCS5- KO cells[1]
to determine its potent activity (IC₅₀ less than 1 μM) against A2780-cis ovarian cancer cells[2]
in western blot analysis[3]

Biochem/physiol Actions

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor.

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC₅₀ of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells

Sima N, et al.

Translational Oncology, 11(4), 1053-1064 (2018)

2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline Alters Autophagosome Maturation, Cellular Lipidomic Profiles, and Expression of Core Pluripotent Factors.

Dan Song et al.

Journal of agricultural and food chemistry, 67(28), 7977-7985 (2019-04-02)

2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), one of the most abundant heterocyclic aromatic amines (HAAs) found in the human diet, is primarily produced during high-temperature meat or fish cooking. While MeIQx has been investigated as a potential carcinogen, the cytotoxicity and related molecular mechanisms

BORC coordinates encounter and fusion of lysosomes with autophagosomes

Jia R, et al.

Autophagy, 13(10), 1648-1663 (2017)

AMPK promotes induction of a tumor suppressor FLCN through activation of TFEB independently of mTOR

Collodet C, et al.

bioRxiv, 499921-499921 (2018)

Melatonin improves bisphenol A-induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK-BLV cells.

Dan Song et al.

Environmental toxicology, 37(7), 1551-1562 (2022-03-04)

The aim of this study was to assess the protective effect and potential mechanism of melatonin against bisphenol A (BPA)-induced apoptosis and oxidative damage in FLK-BLV cells. The results showed that BPA reduced cell viability in a dose- and time-dependent

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Torin2