(−)-Nicotine hydrogen tartrate salt

≥98% (HPLC)

(−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt, (−)-Nicotine ditartrate
Empirical Formula (Hill Notation):
C10H14N2 · 2C4H6O6
CAS Number:
Molecular Weight:
EC Number:
PubChem Substance ID:

Quality Level


≥98% (HPLC)



optical activity

[α]/D +20 to +26°, c = 1.0 in water

storage condition



white to beige


H2O: 20 mg/mL, clear

storage temp.

room temp

SMILES string




InChI key


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(−)-Nicotine hydrogen tartrate salt has been used as an agonist for acetylcholine receptor (AChr).
(−)-Nicotine hydrogen tartrate salt has been used in intracellular calcium imaging.


1 g in glass bottle
50 mg in glass bottle

Biochem/physiol Actions

Nicotine hydrogen tartrate (NHT) is a biodegradable polymer of chitosan. NHT is considered to be more stable than nicotine. Nicotine is highly addictive drug and is indirectly but strongly associated with tobacco related diseases. It helps to discontinue smoking. Nicotine might serve as a therapeutic agent in treating Alzheimer′s disease, Parkinson′s disease and ulcerative colitis.
Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Signal Word



UN 1659 6.1 / PGII

WGK Germany


Flash Point(F)

289.8 °F

Flash Point(C)

143.2 °C

Certificate of Analysis
Certificate of Origin
Mahmoud M Farag et al.
European journal of pharmacology, 720(1-3), 1-6 (2013-11-12)
The aim of this study was to evaluate the effects of chronic nicotine administration on bone mineral homeostasis in rapidly growing young rats in comparison to effects in adult male rats. Two doses of nicotine (3 and 4.5mg/kg/day, as nicotine...
Metabolism and disposition kinetics of nicotine.
Hukkanen J, et al.
Pharmacological Reviews, 57(1), 79-115 (2005)
Nicotine hydrogen tartrate loaded chitosan nanoparticles: Formulation, characterization and in vitro delivery from dry powder inhaler formulation.
Wang H, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 113, 118-131 (2017)
Wesley Drew Gill et al.
Journal of psychopharmacology (Oxford, England), 34(1), 137-144 (2019-11-07)
Adenosine A2a receptors form a mutually inhibitory heteromeric complex with dopamine D2 receptors such that each receptor exhibits lower sensitivity to its agonist after the opposing receptor agonist is bound. This study analyzed the effects of CGS 21680, an adenosine...
All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium.
Radu B M, et al.
Scientific Reports, 7(1), 5083-5083 (2017)

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