SML1236

Sigma-Aldrich

(−)-Nicotine hydrogen tartrate salt

≥98% (HPLC)

Synonym(s):
(−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt, (−)-Nicotine ditartrate
Empirical Formula (Hill Notation):
C10H14N2 · 2C4H6O6
CAS Number:
Molecular Weight:
462.41
EC Number:
PubChem Substance ID:

Quality Level

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +20 to +26°, c = 1.0 in water

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

SMILES string

CN1CCC[C@H]1C2=CC=CN=C2.C

InChI

1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1

InChI key

RYYKFQGHMYGLEL-PPHPATTJSA-N

Looking for similar products? Visit Product Comparison Guide

Application

(−)-Nicotine hydrogen tartrate salt has been used as an agonist for acetylcholine receptor (AChr).
(−)-Nicotine hydrogen tartrate salt has been used in intracellular calcium imaging.

Packaging

1 g in glass bottle
50 mg in glass bottle

Biochem/physiol Actions

Nicotine hydrogen tartrate (NHT) is a biodegradable polymer of chitosan. NHT is considered to be more stable than nicotine. Nicotine is highly addictive drug and is indirectly but strongly associated with tobacco related diseases. It helps to discontinue smoking. Nicotine might serve as a therapeutic agent in treating Alzheimer′s disease, Parkinson′s disease and ulcerative colitis.
Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Signal Word

Danger

RIDADR

UN 1659 6.1 / PGII

WGK Germany

WGK 2

Flash Point(F)

289.8 °F

Flash Point(C)

143.2 °C

Certificate of Analysis
Certificate of Origin
Mahmoud M Farag et al.
European journal of pharmacology, 720(1-3), 1-6 (2013-11-12)
The aim of this study was to evaluate the effects of chronic nicotine administration on bone mineral homeostasis in rapidly growing young rats in comparison to effects in adult male rats. Two doses of nicotine (3 and 4.5mg/kg/day, as nicotine...
Metabolism and disposition kinetics of nicotine.
Hukkanen J, et al.
Pharmacological Reviews, 57(1), 79-115 (2005)
Nicotine hydrogen tartrate loaded chitosan nanoparticles: Formulation, characterization and in vitro delivery from dry powder inhaler formulation.
Wang H, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 113, 118-131 (2017)
Wesley Drew Gill et al.
Journal of psychopharmacology (Oxford, England), 34(1), 137-144 (2019-11-07)
Adenosine A2a receptors form a mutually inhibitory heteromeric complex with dopamine D2 receptors such that each receptor exhibits lower sensitivity to its agonist after the opposing receptor agonist is bound. This study analyzed the effects of CGS 21680, an adenosine...
All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium.
Radu B M, et al.
Scientific Reports, 7(1), 5083-5083 (2017)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.