SML1250

KT203

Name: KT203
Brand: SIGMA
Price: 107.1 USD

≥98% (HPLC)

Synonym(s):

4′-[1-[[2-(Phenylmethyl)-1-piperidinyl]carbonyl]-1H-1,2,3-triazol-4-yl]-[1,1′-biphenyl]-3-carboxylic acid

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5 MG

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$337.00

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₆N₄O₃

CAS Number:

1402612-64-9

Molecular Weight:

466.53

MDL number:

MFCD28118915

UNSPSC Code:

12352200

PubChem Substance ID:

329825743

NACRES:

NA.77

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N1N=NC(C2=CC=C(C3=CC=CC(C(O)=O)=C3)C=C2)=C1)N4CCCCC4CC5=CC=CC=C5

InChI

1S/C28H26N4O3/c33-27(34)24-10-6-9-23(18-24)21-12-14-22(15-13-21)26-19-32(30-29-26)28(35)31-16-5-4-11-25(31)17-20-7-2-1-3-8-20/h1-3,6-10,12-15,18-19,25H,4-5,11,16-17H2,(H,33,34)

Inchi Key

SSSCOJOXPDDHOO-UHFFFAOYSA-N

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Show Differences

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This Item	SML1308	SML1249	SML1248
Sigma-Aldrich SML1250 KT203	Sigma-Aldrich SML1308 KT195	Sigma-Aldrich SML1249 KT185	Sigma-Aldrich SML1248 KT182
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 20 mg/mL, clear	solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 10 mg/mL, clear
color white to beige	color white to beige	color white to beige	color white to beige

Biochem/physiol Actions

KT203 is a very potent, selective inhibitor of ABHD6 (IC50 = 0.82 nM). KT203 inhibits ABHD6 activity in the liver, but not the brain following ip injection in mice.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

035M4604V

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Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6).

Ku-Lung Hsu et al.

Journal of medicinal chemistry, 56(21), 8270-8279 (2013-10-25)

α/β-Hydrolase domain containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) to regulate certain forms of cannabinoid receptor-dependent signaling in the nervous system. The full spectrum of ABHD6 metabolic activities and functions is currently

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KT203