This product is tested for solubility in DMSO. The rate varies from lot to lot, however the minimum concentration is 5 mg/mL. Warming may be required. Other published solvents include Dimethylformamide and methanol. No rate is provided. Ethanol may also be an option, the end user would have to determine experimentally. Chloroform is not listed as a solvent in any published resources. Please see the link below to access a sample or lot specific Certificate of Anaysis to review solubility testing:
https://www.sigmaaldrich.com/US/en/product/sigma/sml1296#product-documentation
SML1296
6-Thio-2′-Deoxyguanosine
≥97% (HPLC)
Synonym(s):
2′-Ddeoxy-6-thio-guanosine, 2′-Deoxy-6-thioguanosine, 2′-Deoxythioguanosine, 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine, 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione (7CI,8CI), 6-Thio-dG, NSC 71261
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SMILES string
S=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)O3)C=N2)N=C(N)N1
InChI
1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5-,6-/m1/s1
InChI key
SCVJRXQHFJXZFZ-HSUXUTPPSA-N
assay
≥97% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
1 of 4
This Item | |||
|---|---|---|---|
| assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥97% |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| solubility DMSO: 5 mg/mL, clear (warmed) | solubility H2O: 10 mg/mL, clear | solubility H2O: 10 mg/mL (clear solution) | solubility acetic acid: water (1:1): 50 mg/mL |
| color white to brown | color white to beige | color white to beige | color - |
Application
6-Thio-2′-Deoxyguanosine has been used in secreted luciferase enzyme activity in tonsillar cancer cells.[1]
Biochem/physiol Actions
6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres.
6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. 6-Thio-2′-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Haoran Yu et al.
Virology, 521, 1-19 (2018-06-05)
Adenosine plays an important role in cell death and differentiation as well as in tumorigenesis and the intra- and extra-cellular levels range from nanomolar to millimolar levels under various physiological or pathophysiological conditions. Here we report that adenosine can activate
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I would like to learn solubility of this product , Can we dissolve it in the ethanol or chloroform, what is the solubility in the water or buffers
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