SML1311

Sigma-Aldrich

Rubone

≥98% (HPLC)

Synonym(s):
2′-Hydroxy-2,4,4′,5,6′-pentamethoxychalcone, (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-2-propen-1-one
Empirical Formula (Hill Notation):
C20H22O7
CAS Number:
Molecular Weight:
374.38
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

yellow to orange

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Rubone has strong anticancer activity. Rubone and paclitaxel (PTX) combination therapy retarded cancer cell growth, migration and cancer stem-like cells (CSC) population growth.
Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells with wild-type or mutated p53. Rubone potently inhibits growth of hepatocellular carcinoma in a mouse xenograft model. Rubone does not effect the growth of nontumorigenic human hepatocytes.
Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Chong Chen et al.
Oncogene, 38(23), 4527-4539 (2019-02-12)
The altered metabolism and acidic microenvironment plays an important role in promoting tumor malignant characteristics. A small population of cancer stem cells (CSCs) were considered as a therapy target to reserve tumor relapse, resistance, and metastasis. However, the molecular mechanism...
Small molecule targeting miR-34a for cancer therapy
Xiao Z, et al.
Molecular & Cellular Oncology, 2(1), e977160-e977160 (2015)
Micellar delivery of miR-34a modulator rubone and paclitaxel in resistant prostate cancer
Wen D, et al.
Cancer Research, 77(12), 3244-3254 (2017)

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