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SML1510

Sigma-Aldrich

SR9238

≥98% (HPLC)

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Synonym(s):
Ethyl 5-((2,4,6-trimethyl-N-((3′-(methylsulfonyl)-[1,1′-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate
Empirical Formula (Hill Notation):
C31H33NO7S2
CAS Number:
Molecular Weight:
595.73
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

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SML1517SML0711SML2037
Sigma-Aldrich

Sigma-Aldrich

SML1510

SR9238

SR9243 ≥98% (HPLC)

Sigma-Aldrich

SML1517

SR9243

Sigma-Aldrich

Sigma-Aldrich

SML0711

RS504393

SR2595 ≥98% (HPLC)

Sigma-Aldrich

SML2037

SR2595

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

white to beige

color

white to faint brown

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 1 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

Biochem/physiol Actions

SR9238 is liver selective LXR inverse agonist with high potency for both LXRα and LXRβ with an IC50 of 214 nM for LXRα and 43 nM for LXRβ. Metabolic syndrome is often accompanied by liver problems, such as fatty liver (nonalcoholic hepatosteatosis), associated with increased lipogenesis. Liver X receptors α and β (LXRα and LXRβ) are known to induce lipogenesis by increasing transcription of lipogenic enzyme genes, so it was hoped LXR antagonists might be of use in fatty liver. In a mouse model of nonalcoholic hepatosteatosis, SR9238 reduced the expression of lipogenic genes, and suppressed hepatic lipogenesis, inflammation and hepatic lipid accumulation. It was also effective in reduction of hepatic fibrosis in another study. Additionally in diet induced obese mice, SR9238 suppressed plasma cholesterol levels.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Grace Ampem et al.
Cell and tissue research, 378(1), 81-96 (2019-04-24)
Self-renewal of macrophages is important for the healthy development and replenishment of tissue-resident macrophage pools. How this mechanism is controlled by endocrine signals is still largely unexplored. Here, we show that the endocrine disruptor bisphenol A (BPA) increases macrophage self-renewal.

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