SML1527

Abiraterone acetate

≥98% (HPLC), CYP17A1 inhibitor, powder

• Synonym(s): CB 7598, 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate
• Empirical Formula (Hill Notation): C₂₆H₃₃NO₂
• CAS Number: 154229-18-2
• Molecular Weight: 391.55
• MDL number: MFCD00934213
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825944
• NACRES: NA.77

Properties

• Product Name: Abiraterone acetate, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• storage temp.: −20°C
• SMILES string: C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CN=C5
• InChI: 1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1
• InChI key: UVIQSJCZCSLXRZ-UBUQANBQSA-N
• Gene Information: human ... CYP17A1(1586)

Description

Application

Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.[1]

Biochem/physiol Actions

Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer.[2][3] Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.

Safety Information

• pictograms: GHS08,GHS09
• signalword: Danger
• hcodes: H360F,H373,H410
• pcodes: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Hazard Classifications: Aquatic Chronic 1 - Repr. 1B - STOT RE 2
• target_organs: Endocrine system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable