SML1567

Sigma-Aldrich

MCB-613

≥98% (HPLC)

Synonym(s):
4-Ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone
Empirical Formula (Hill Notation):
C20H20N2O
CAS Number:
Molecular Weight:
304.39
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

General description

MCB-613 (4-Ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone) belongs to the chalcone class of compounds. It is an anti-neoplastic compound.

Application

MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs).
MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death
Hossain MM, et al.
Testing, 9(14), 11707-11707 (2018)
Lei Wang et al.
Cancer cell, 28(2), 240-252 (2015-08-13)
By integrating growth pathways on which cancer cells rely, steroid receptor coactivators (SRC-1, SRC-2, and SRC-3) represent emerging targets in cancer therapeutics. High-throughput screening for SRC small molecule inhibitors (SMIs) uncovered MCB-613 as a potent SRC small molecule "stimulator" (SMS)....

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