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SML1596

Sigma-Aldrich

PPZ2

≥98% (HPLC)

Synonym(s):

2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-N-(2-ethoxyphenyl)acetamide, 4-(2,3-Dimethylphenyl)-N-(2-ethoxyphenyl)-1-piperazineacetamide

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5 MG
$112.10

$112.10

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5 MG
$112.10

About This Item

Empirical Formula (Hill Notation):
C22H29N3O2
CAS Number:
Molecular Weight:
367.48
UNSPSC Code:
12352200
NACRES:
NA.25

$112.10

List Price$118.00Save 5%
Web-Only Promotion

In StockDetails


Request a Bulk Order

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

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Show Differences

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This Item
SML1393SML1334SML0524
PPZ2 ≥98% (HPLC)

SML1596

PPZ2

WH-4-023 ≥98% (HPLC)

SML1334

WH-4-023

ML277 ≥98% (HPLC)

SML0524

ML277

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

PPZ2 is an activator of DAG-activated TRPC3/TRPC6/TRPC7 channels. Neurotrophic.
PPZ2 selectively activates DAG-activated TRPC3/TRPC6/TRPC7 channels. PPZ2 activates native TRPC6-like channels in smooth muscle cells isolated from the rabbit portal vein. PPZ2 induces BDNF-like neurite growth and neuroprotection in cultured neurons.
TRPCs are cation channels, mainly permeable to Ca2+ ions.[1] TRPC6 plays a crucial role in tumor development.[2] TRPC3 controls fibronectin expression, thereby regulating wound healing process.[3] TRPC7 is involved in the proliferation of osteoblasts.[4]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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