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SML1639

Sigma-Aldrich

BRD3308

≥98% (HPLC)

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Synonym(s):
4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide
Empirical Formula (Hill Notation):
C15H14FN3O2
CAS Number:
Molecular Weight:
287.29
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(NC1=CC=C(C(NC2=CC=C(F)C=C2N)=O)C=C1)=O

InChI

1S/C15H14FN3O2/c1-9(20)18-12-5-2-10(3-6-12)15(21)19-14-7-4-11(16)8-13(14)17/h2-8H,17H2,1H3,(H,18,20)(H,19,21)

InChI key

RRJDFENBXIEAPD-UHFFFAOYSA-N

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BRD3308 ≥98% (HPLC)

Sigma-Aldrich

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BRD3308

RIPGBM ≥98% (HPLC)

Sigma-Aldrich

SML2682

RIPGBM

NPBA ≥98% (HPLC)

Sigma-Aldrich

SML2736

NPBA

AZD1152-HQPA ≥98% (HPLC)

Sigma-Aldrich

SML0268

AZD1152-HQPA

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

faint brown to very dark brown-red

color

white to beige

color

white to beige

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >15 mg/mL

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

Biochem/physiol Actions

BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs. IC50 values of 1.08 μM and 1.15 μM for HDAC1 and HDAC2, respectively. BRD3308 protected pancreatic β cells, suppressing inflammatory cytokine-induced apoptosis and increasing insulin release without the toxicity associated with HDAC1 and HDAC2 inhibitors. In a rat model of type 2 diabetes, BRD3308 reduced hyperglycemia and increased insulin secretion without affecting weight gain. In another study, BRD3308 was found to activate HIV-1 transcription, disrupting HIV-1 latency.
BRD3308 promotes outgrowth of HIV-1 (human immunodeficiency virus 1) from inactive infected patient cells. It helps to increase β-cell proliferation.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.
Dirice E, et al.
The Journal of Biological Chemistry, 292(43), 17598-17608 (2017)
International Review of Cell and Molecular Biology, 300-300 (2017)
S V Demyanenko et al.
Brain research bulletin, 162, 151-165 (2020-06-28)
Epigenetic processes play important roles in brain responses to ischemic injury. We studied effects of photothrombotic stroke (PTS, a model of ischemic stroke) on the intracellular level and cellular localization of histone deacetylases HDAC3, HDAC4 and HDAC6 in the rat

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