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SML1714

Sigma-Aldrich

DCAI

≥95% (HPLC)

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Synonym(s):
2-(4,6-Dichloro-2-methyl-1h-indol-3-yl)ethanamine, 4,6-Dichloro-2-methyl-3-aminoethylindole
Empirical Formula (Hill Notation):
C11H12Cl2N2
CAS Number:
Molecular Weight:
243.13
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥95% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

InChI

1S/C11H12Cl2N2/c1-6-8(2-3-14)11-9(13)4-7(12)5-10(11)15-6/h4-5,15H,2-3,14H2,1H3

InChI key

JCTJISIFGZHOFY-UHFFFAOYSA-N

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SML0515SML0151SML2710
DCAI ≥95% (HPLC)

Sigma-Aldrich

SML1714

DCAI

DCAP ≥95% (HPLC)

Sigma-Aldrich

SML0515

DCAP

CCT036477 ≥98% (HPLC)

Sigma-Aldrich

SML0151

CCT036477

ZCZ011 ≥98% (HPLC)

Sigma-Aldrich

SML2710

ZCZ011

form

powder

form

powder

form

powder

form

powder

color

white to brown

color

white to beige

color

white to tan

color

white to beige

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: ≥20 mg/mL (warm to 60°C)

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

storage temp.

room temp

storage temp.

−20°C

storage temp.

2-8°C

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

Biochem/physiol Actions

DCAI, an Inactive Ras, is bound to a GDP and activated by SOS (son of sevenless, among others), which converts it to the active GTP form. DCAI is a known binder to Ras, which inhibits SOS nucleotide exchange, inhibiting Ras activation.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Jon J G Winter et al.
Journal of medicinal chemistry, 58(5), 2265-2274 (2015-02-20)
Constitutively active mutant KRas displays a reduced rate of GTP hydrolysis via both intrinsic and GTPase-activating protein-catalyzed mechanisms, resulting in the perpetual activation of Ras pathways. We describe a fragment screening campaign using X-ray crystallography that led to the discovery
Till Maurer et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(14), 5299-5304 (2012-03-21)
The Ras gene is frequently mutated in cancer, and mutant Ras drives tumorigenesis. Although Ras is a central oncogene, small molecules that bind to Ras in a well-defined manner and exert inhibitory effects have not been uncovered to date. Through
Thi B Trinh et al.
ACS combinatorial science, 18(1), 75-85 (2015-12-10)
Cyclic peptides have great potential as therapeutic agents and research tools. However, their applications against intracellular targets have been limited, because cyclic peptides are generally impermeable to the cell membrane. It was previously shown that fusion of cyclic peptides with

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