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SML1941

Sigma-Aldrich

CGP3466B maleate salt

≥98% (HPLC)

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Synonym(s):
CGP 3466B, Dibenz[b,f]oxepin-10-methanamine, N-methyl-N-2-propyn-1-yl-, (2Z)-2-butenedioate (1:1), N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-methyl-N-(2-propynyl)amine monomaleic acid salt, Omigapil maleate salt, TCH346
Empirical Formula (Hill Notation):
C19H17NO · C4H4O4
CAS Number:
Molecular Weight:
391.42
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C19H17NO.C4H4O4/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19;5-3(6)1-2-4(7)8/h1,4-11,13H,12,14H2,2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

SQAZQLMBEHYFJA-BTJKTKAUSA-N

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O111P8013I7379
Sigma-Aldrich

SML1941

CGP3466B maleate salt

Octoclothepin maleate salt solid

O111

Octoclothepin maleate salt

Pargyline hydrochloride

P8013

Pargyline hydrochloride

Imipramine hydrochloride ≥99% (TLC)

I7379

Imipramine hydrochloride

form

powder

form

solid

form

powder or crystals

form

powder

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >21 mg/mL

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

H2O: 50 mg/mL

color

white to beige

color

white

color

-

color

white

Biochem/physiol Actions

CGP3466B, also known as Omigapil maleate and TCH346, is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). It has been shown to have neuroprotective activity and received U.S. FDA Fast Track Designation for the treatment of congenital muscular dystrophy in May 2016.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Natasha T Snider et al.
PloS one, 11(8), e0160982-e0160982 (2016-08-12)
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) signals during cellular stress via several post-translational modifications that change its folding properties, protein-protein interactions and sub-cellular localization. We examined GAPDH properties in acute mouse liver injury due to ethanol and/or acetaminophen (APAP) treatment.
Prasun Guha et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1417-1422 (2016-01-21)
Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin. It is also neurotoxic and broadly cytotoxic, leading to overdose deaths. We demonstrate that the cytotoxic actions of cocaine reflect selective enhancement of
Qing Yu et al.
PloS one, 8(6), e65468-e65468 (2013-06-14)
Congenital muscular dystrophy is a distinct group of diseases presenting with weakness in infancy or childhood and no current therapy. One form, MDC1A, is the result of laminin alpha-2 deficiency and results in significant weakness, respiratory insufficiency and early death.

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