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MilliporeSigma

SML1946

AM-9074

≥98% (HPLC)

Synonym(s):

(R)-1-(4-((5-Methoxypyridin-3-yl)oxy)-5-(tetrahydro-2H-pyran-3-yl)pyridin-2-yl)-3-methylurea, Urea, N-[4-[(5-methoxy-3-pyridinyl)oxy]-5-[(3R)-tetrahydro-2H-pyran-3-yl]-2-pyridinyl]-N′-methyl-

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5 MG

$88.40

25 MG

$419.00

$88.40

List Price$104.00Save 15%

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About This Item

Empirical Formula (Hill Notation):
C18H22N4O4
CAS Number:
Molecular Weight:
358.39
UNSPSC Code:
12352200
NACRES:
NA.77

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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CNC(NC1=CC(OC2=CC(OC)=CN=C2)=C([C@H]3CCCOC3)C=N1)=O

InChI

1S/C18H22N4O4/c1-19-18(23)22-17-7-16(26-14-6-13(24-2)8-20-9-14)15(10-21-17)12-4-3-5-25-11-12/h6-10,12H,3-5,11H2,1-2H3,(H2,19,21,22,23)/t12-/m0/s1

InChI key

APSOPISMEDAYTH-LBPRGKRZSA-N

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This Item
SML2819SML2582SML1336
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

AM-9074 is a potent activator of glucokinase, which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-9074 had an EC50 value of 160 nM with good solubility, oral bioavailability and acceptable clearance in rodents, and was shown to lower plasma glucose levels.
Glucokinase activator

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Todd J Kohn et al.
ACS medicinal chemistry letters, 7(7), 666-670 (2016-07-21)
Two 1-(4-aryl-5-alkyl-pyridin-2-yl)-3-methylurea glucokinase activators were identified with robust in vivo efficacy. These two compounds possessed higher solubilities than the previously identified triaryl compounds (i.e., AM-2394). Structure-activity relationship studies are presented along with relevant pharmacokinetic and in vivo data.

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