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SML2460

Sigma-Aldrich

SK33

≥98% (HPLC)

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Synonym(s):
3-[3,5-Bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
Empirical Formula (Hill Notation):
C20H13F9N2O3
CAS Number:
1928724-23-5
Molecular Weight:
500.31

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(C(NC1=CC(C(F)(F)F)=C(C#N)C=C1)=O)(C)COC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

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This Item
SML2248SML2336S5576
SK33 ≥98% (HPLC)

Sigma-Aldrich

SML2460

SK33

SK-216 ≥98% (HPLC)

Sigma-Aldrich

SML2248

SK-216

Sk052-145-2 ≥97% (HPLC)

Sigma-Aldrich

SML2336

Sk052-145-2

SKA-31 ≥98% (HPLC)

Sigma-Aldrich

S5576

SKA-31

form

powder

form

powder

form

powder

form

solid

color

white to beige

color

white to beige

color

white to beige

color

-

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 0.5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

−20°C

Biochem/physiol Actions

SK33, a trifluoromethylated enobosarm analog, is a cell and brain penetrant, tissue selective and highly potent anti-androgen that reduces androgen receptor (AR) transcriptional activity. SK33 induces cell cycle arrest at G1 phase. It exhibits increased efficacy against acquired anti-androgen resistance prostate cancer cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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D Alwyn Dart et al.
Molecular cancer therapeutics, 17(9), 1846-1858 (2018-06-14)
Prostate cancer often develops antiandrogen resistance, possibly via androgen receptor (AR) mutations, which change antagonists to agonists. Novel therapies with increased anticancer activity, while overcoming current drug resistance are urgently needed. Enobosarm has anabolic effects on muscle and bone while
Salvatore Ferla et al.
Bioorganic & medicinal chemistry letters, 26(15), 3636-3640 (2016-06-16)
Prostate cancer is a major cause of male death worldwide and the identification of new and improved treatments is constantly required. Among the available options, different non-steroidal androgen receptor (AR) antagonists are approved also to treat castration-resistant forms. Most of

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