The solubility of this material has not been investigated. According to DrugBank, this compound is water soluble at 12.8 ug/ml. Please see the link below to review this entry:
https://go.drugbank.com/drugs/DB01254
SML2589
Dasatinib
≥98% (HPLC), powder, protein kinases inhibitor
Synonym(s):
BMS 354825, BMS-354825, BMS354825, N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
Select a Size
About This Item
Skip To
Product Name
Dasatinib, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCO)=N1
InChI
1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChI key
ZBNZXTGUTAYRHI-UHFFFAOYSA-N
Gene Information
human ... ABL1(25), BLK(640), EPHA2(1969), FGR(2268), FRK(2444), FYN(2534), HCK(3055), KIT(3815), LCK(3932), LYN(4067), PDGFRB(5159), SRC(6714), SRMS(6725), YES1(7525)
Looking for similar products? Visit Product Comparison Guide
Related Categories
1 of 4
This Item | SML1205 | SML2382 | SML2632 |
---|---|---|---|
form powder | form powder | form powder | form powder |
assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay ≥98% (HPLC) |
storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear |
color white to beige | color white to light brown | color white to beige | color white to beige |
Gene Information human ... ABL1(25), BLK(640), EPHA2(1969), FGR(2268), FRK(2444), FYN(2534), HCK(3055), KIT(3815), LCK(3932), LYN(4067), PDGFRB(5159), SRC(6714), SRMS(6725), YES1(7525) | Gene Information - | Gene Information - | Gene Information - |
Application
- as a protein kinase inhibitor to study its effects on macrophage polarization, lipogenesis, western diet-induced progression of simple steatosis into steatohepatitis (NASH), and liver fibrosis in mice[1]
- as an SRC tyrosine kinase inhibitor to study its effects on hepatocellular carcinoma cells[2]
- as a tyrosine kinase inhibitor to study its effects on autophagy in neuronal cells[3]
Biochem/physiol Actions
signalword
Danger
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - STOT RE 1
target_organs
Gastro-intestinal system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
-
How can I dilute Dasatinib without dmso? need an alternative for dmso.
1 answer-
Helpful?
-
-
Guten Abend, wie lange ist dieses Produkt bei -20 Grad, gelöst, haltbar?
1 answer-
Dasatinib is soluble in DMSO at a concentration of 2 mg/mL. Solutions in DMSO may be stored in the freezer at -20°C for up to two months. Dilutions can be made into aqueous buffers, but aqueous solutions of Dasatinib should be used the same day that it is prepared and not stored.
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service