Skip to Content
MilliporeSigma

SML2589

Sigma-Aldrich

Dasatinib

≥98% (HPLC), powder, protein kinases inhibitor

Synonym(s):

BMS 354825, BMS-354825, BMS354825, N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide

Slide 1 of 1
Sign Into View Organizational & Contract Pricing

Select a Size

50 MG
$49.60

$49.60


Estimated to ship onJuly 16, 2025Details


Request a Bulk Order

Select a Size

Change View
50 MG
$49.60

About This Item

Empirical Formula (Hill Notation):
C22H26ClN7O2S
CAS Number:
Molecular Weight:
488.01
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

$49.60


Estimated to ship onJuly 16, 2025Details


Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Dasatinib, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCO)=N1

InChI

1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChI key

ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SML1205SML2382SML2632
BVT.2733 ≥98% (HPLC)

SML1205

BVT.2733

SC75741 ≥97% (HPLC)

SML2382

SC75741

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to light brown

color

white to beige

color

white to beige

Gene Information

human ... ABL1(25), BLK(640), EPHA2(1969), FGR(2268), FRK(2444), FYN(2534), HCK(3055), KIT(3815), LCK(3932), LYN(4067), PDGFRB(5159), SRC(6714), SRMS(6725), YES1(7525)

Gene Information

-

Gene Information

-

Gene Information

-

Application

Dasatinib has been used:
  • as a protein kinase inhibitor to study its effects on macrophage polarization, lipogenesis, western diet-induced progression of simple steatosis into steatohepatitis (NASH), and liver fibrosis in mice[1]
  • as an SRC tyrosine kinase inhibitor to study its effects on hepatocellular carcinoma cells[2]
  • as a tyrosine kinase inhibitor to study its effects on autophagy in neuronal cells[3]

Biochem/physiol Actions

Dasatinib is a thiazole-carboxamide compound that inhibits a broad spectrum of protein kinases such as breakpoint cluster region-tyrosine protein kinase ABL (Bcr-Abl), Btk family members, platelet-derived growth factor receptor α/β (PDGFR-α/β), and ephrin receptor kinase. It also inhibits Src-family kinases such as SRC tyrosine kinase, and lymphocyte-specific protein kinase (LCK).[4] Dasatinib exhibits certain effects on hematopoietic cells like suppressing natural killer cell toxicity, inhibiting T lymphocytes activation and proliferation, and influencing platelet activation.[1] It is also studied in the treatment of chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).[4]

signalword

Danger

Hazard Classifications

Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - STOT RE 1

target_organs

Gastro-intestinal system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

1–2 of 2 Questions  
  1. How can I dilute Dasatinib without dmso? need an alternative for dmso.

    1 answer
    1. The solubility of this material has not been investigated. According to DrugBank, this compound is water soluble at 12.8 ug/ml. Please see the link below to review this entry:
      https://go.drugbank.com/drugs/DB01254

      Helpful?

  2. Guten Abend, wie lange ist dieses Produkt bei -20 Grad, gelöst, haltbar?

    1 answer
    1. Dasatinib is soluble in DMSO at a concentration of 2 mg/mL. Solutions in DMSO may be stored in the freezer at -20°C for up to two months. Dilutions can be made into aqueous buffers, but aqueous solutions of Dasatinib should be used the same day that it is prepared and not stored.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service