SML2644

NCGC00135472

Name: NCGC00135472
Brand: SIGMA
Price: 77.43 USD
Availability: InStock

≥98% (HPLC)

Synonym(s):

3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]-benzamide, C2A

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₄F₂N₄O

CAS Number:

862811-76-5

Molecular Weight:

364.35

UNSPSC Code:

12352200

NACRES:

NA.77

Key Documents

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

Fc1c(ccc(c1)C(=O)Nc2cc(ccc2)c3nc4[n](c3C)cccn4)F

InChI

1S/C20H14F2N4O/c1-12-18(25-20-23-8-3-9-26(12)20)13-4-2-5-15(10-13)24-19(27)14-6-7-16(21)17(22)11-14/h2-11H,1H3,(H,24,27)

InChI key

YOVZCQZBMAXLPR-UHFFFAOYSA-N

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Show Differences

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This Item	SML0016	SML1626	SML0333
Sigma-Aldrich SML2644 NCGC00135472	Sigma-Aldrich SML0016 CCG-63802	Sigma-Aldrich SML1626 TFCA	Sigma-Aldrich SML0333 NVP-BHG712
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. −20°C
solubility DMSO: 2 mg/mL, clear	solubility DMSO: ≥5 mg/mL (;warmed DMSO)	solubility DMSO: 25 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
color white to beige	color yellow	color white to beige	color white to beige

Biochem/physiol Actions

NCGC00135472 (C2A) is a resolvin D1 (RvD1) mimetic that activates resolving D1 receptor (DRV1/GPR32) and stimulate phagocytosis of serum-treated zymosan. NCGC00135472 enhances macrophage phagocytosis of live E. coli.

resolvin D1 (RvD1) mimetic that activates DRV1/GPR32

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000076795

0000076796

0000072555

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Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions.

Nan Chiang et al.

Cell chemical biology, 26(2), 244-254 (2018-12-18)

Resolution of acute inflammation is governed, in part, by specialized pro-resolving mediators, including lipoxins, resolvins, protectins, and maresins. Among them, resolvin D1 (RvD1) exhibits potent pro-resolving functions via activating human resolvin D1 receptor (DRV1/GPR32). RvD1 is a complex molecule that requires

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NCGC00135472