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SML2647

Sigma-Aldrich

CA3

≥97% (HPLC)

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Synonym(s):
1,1′-[[9-(Hydroxyimino)-9H-fluorene-2,7-diyl]bis(sulfonyl)]bis-piperidine, 2,7-bis(1-Piperidinylsulfonyl)-9H-fluoren-9-one oxime, CIL56
Empirical Formula (Hill Notation):
C23H27N3O5S2
CAS Number:
300802-28-2
Molecular Weight:
489.61
MDL number:
MFCD00323348

Assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

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SML3197C5732SML1097
CA3 ≥97% (HPLC)

Sigma-Aldrich

SML2647

CA3

CA77.1 ≥98% (HPLC)

Sigma-Aldrich

SML3197

CA77.1

CA-074 ≥99% (TLC)

Sigma-Aldrich

C5732

CA-074

BC8-15 ≥98% (HPLC)

Sigma-Aldrich

SML1097

BC8-15

form

powder

form

powder

form

powder

form

powder

color

white to beige

color

white to beige

color

-

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

methanol: 1 mg/mL, clear, colorless

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

Biochem/physiol Actions

CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Shumei Song et al.
Molecular cancer therapeutics, 17(2), 443-454 (2017-11-24)
Mounting evidence suggests that the Hippo coactivator Yes-associated protein 1 (YAP1) is a major mediator of cancer stem cell (CSC) properties, tumor progression, and therapy resistance as well as often a terminal node of many oncogenic pathways. Thus, targeting YAP1
Sina Stern et al.
Neuron, 109(21), 3436-3455 (2021-09-12)
An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how the two aspects are interwoven. Genetic loss-of-function experiments determine that the small GTPase RhoA relays extracellular inhibitory signals

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