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MilliporeSigma

SML2800

Sigma-Aldrich

Proscillaridin A

≥90% (HPLC)

Synonym(s):

Proscillaridin A, (3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide, 3-(6-Deoxy-α-L-mannopyranosyloxyl)-14-hydroxybufa-4,20,22-trienolide, Scillarenin 3β-rhamnoside

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About This Item

Empirical Formula (Hill Notation):
C30H42O8
CAS Number:
466-06-8
Molecular Weight:
530.65
MDL number:
MFCD00214065
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Quality Level

100

assay

≥90% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

C[C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O[C@]5([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)C=C4CC[C@@]3([H])[C@@]1(O)CC[C@@H]2C6=COC(C=C6)=O

InChI

1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19?,20?,21?,22?,24-,25+,26+,27-,28?,29?,30?/m0/s1

InChI key

MYEJFUXQJGHEQK-RLQJMXQZSA-N

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Show Differences

1 of 4

This Item
PHL82774SML2747SML2492
Proscillaridin A ≥90% (HPLC)

Sigma-Aldrich

SML2800

Proscillaridin A

Proscillaridin A phyproof® Reference Substance

PHL82774

Proscillaridin A

Forsythiaside A ≥98% (HPLC)

Sigma-Aldrich

SML2747

Forsythiaside A

Engeletin ≥98% (HPLC)

Sigma-Aldrich

SML2492

Engeletin

assay

≥90% (HPLC)

assay

≥90.0% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

-

form

powder

form

powder

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

-

color

white to beige

color

white to beige

Biochem/physiol Actions

Proscillaridin A, a cardiac glycoside, is an antiarrhythmic drug that enhances DNMT inhibitors and HDAC inhibitors activity. Combination of decitabine with proscillaridin A produced profound gene expression reprogramming associated with down-regulation of 153 epigenetic regulators including SYMD3 and KDM8. Proscillaridin A was recently identified as a potent anti-HBV agent (IC50 = 7.2?nM).

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000229019
0000229019
0000229020
0000229020
0000161800

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Noël J-M Raynal et al.
Molecular cancer therapeutics, 16(2), 397-407 (2016-12-17)
Epigenetic drugs, such as DNA methylation inhibitors (DNMTi) or histone deacetylase inhibitors (HDACi), are approved in monotherapy for cancer treatment. These drugs reprogram gene expression profiles, reactivate tumor suppressor genes (TSG) producing cancer cell differentiation and apoptosis. Epigenetic drugs have
Amara Maryam et al.
Oxidative medicine and cellular longevity, 2018, 3853409-3853409 (2018-03-27)
Cardiac glycosides are natural compounds used for the treatment of cardiovascular disorders. Although originally prescribed for cardiovascular diseases, more recently, they have been rediscovered for their potential use in the treatment of cancer. Proscillaridin A (PSD-A), a cardiac glycoside component
Kaori Okuyama-Dobashi et al.
Scientific reports, 5, 17047-17047 (2015-11-26)
Sodium taurocholate cotransporting polypeptide (NTCP) has been reported as a functional receptor for hepatitis B virus (HBV) infection. However, HBV could not efficiently infect HepG2 cells expressing NTCP (NTCP-HepG2 cells) under adherent monolayer-cell conditions. In this study, NTCP was mainly

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